Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats

نویسندگان

  • Akram Ahangarpour Health Research institute, Diabetes Research Center, Dept of Physiology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Ayob Jabari Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  • Hamid Heidari Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran and Department of Physiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran
  • Hamid Malekshahi Nia Department of sport physiology, Faculty of physical education and sport science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
چکیده مقاله:

Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D.  aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed. Results: D. aucheri has highly significant blood glucose lowering effect. Administration of the extract to diabetic rats resulted in a remarkable change in serum lipid profiles, insulin and leptin levels relative to diabetic group. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats. Conclusion: D. aucheri could be useful in treatment of diabetes. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others.

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antidiabetic and hypolipidemic effects of dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats

objective(s):the present study investigated the antidiabetic and hypolipidemic properties of dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. materials and methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of d.  aucheri (100, 200 and 400 mg/kg bw) or glibenclamide (0.25 mg/kg) f...

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Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice

OBJECTIVE Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice. MATERIALS AND METHODS In this investigation, 70 adult...

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عنوان ژورنال

دوره 17  شماره 10

صفحات  808- 814

تاریخ انتشار 2014-10-01

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